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KMID : 0603820130190040344
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 4 p.344 ~ p.347
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Effect of House Dust Mite and CCL2 on S100A8 and S100A9 Expression in Human Monocytes
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Kim In-Sik
Kim Eun-Hye
Kim Do-Hyung
Kim Jung-Seok
Lee Ji-Sook
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Abstract
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The S100A8 and S100A9 proteins play important roles in inflammatory diseases. The house dust mite acts as a major allergen that induces allergic diseases. We investigated the effect of the house dust mite on S100A8 and S100A9 protein expression in monocytes. We also examined the effect of CCL2, a powerful monocyte chemoattractant, on the expression of both proteins. Extract of Dermatophagoides pteronissinus (DP), recombinant Der p 1 and Der p 2, or CCL2 had no effect on S100A8 and S100A9 expression in human monocytic THP-1 cells. Monocytes were isolated from healthy donors and treated with DP, Der p 1, and Der p 2. S100A8 expression in monocytes increased after a 24 h stimulation with DP, Der p 1, and Der p 2, and CCL2 also increased S100A8 production. However, S100A9 expression in monocytes was not altered by DP, Der p 1, Der p 2, or CCL2. These results indicate that house dust mite and CCL2 may trigger an inflammatory response by altering S100A8 expression.
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KEYWORD
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S100A8, S100A9, House dust mite, CCL2, Monocytes
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